Buspirone

In a 21-day, open, multicenter, dose-escalation study, 13 children and 12 adolescents with anxiety disorder and 14 healthy adults, took bus-pirone 5-30 mg bd titrated over 3 weeks (20c). Buspirone was generally safe and well tolerated at doses up to 30 mg in adolescents and adults and in most of the children. The most common adverse events in children and adolescents were light-headedness (68 ), headache (48 ), and dyspepsia (20 ) two children withdrew from the study at the higher doses (15 mg...

Loxapine

Hematologic Three cases of leukocytosis attributed to loxapine have been reported all resolved when loxapine was withdrawn (71A). Olanzapine (SEDA-23, 64 SEDA-24, 66 SEDA-25, 64) There have been no adequate comparisons of olanzapine with clozapine (SEDA-23, 64 SEDA-25, 53). The aim of a recent study by Lilly Research Laboratories was to compare olanzapine with clozapine after 18 weeks of double-blind treatment in 220 schizophrenic patients eligible for treatment with clozapine conclusions were...

Coagulation factor gene therapy

Phase I trials of gene therapy in hemophilia A and B, to determine safety and efficacy, are currently under way (46R). The hazards of current vectors include insertion mutagenesis, immunogenesis, hepatotoxic-ity, and carcinogenic effects. In particular, retro-viral vectors have a considerable carcinogenic potential. Adenoviruses, which do not integrate into the genome and consequently have only a transient effect, are considered to be safer. Also adeno-associated viruses have a low pathogenic...

Quinine And Congeners

(SED-14, 962 SEDA-23, 307 SEDA-24, 333) Quinine remains effective against all Plasmodium species, and is the drug of choice for the management of severe malaria in most areas of the world, either alone or with other antimalarial drugs. Well-known adverse effects include nausea, tinnitus, dizziness, and hypoglycemia. Cheaper and more convenient alternatives to intravenous quinine are being explored in resource-poor settings. A population pharma-cokinetic study of intramuscular quinine (loading...

Mri Contrast Agents

Gadolinium (SEDA-24, 256 SEDA-25, 562) Adverse events associated with the non-ionic gadolinium-based contrast agent gadodiamide have been reported in 1-2 of patients. Most of the commonly reported adverse events have been headache, dizziness, or nausea and vomiting. The safety and effectiveness of gadodiamide-enhanced magnetic resonance angiography (MRA) with single and triple doses in the assessment of abdominal arterial stenosis has been investigated in 105 patients, of whom 53 (aged 45-83...

Gentamicin

Nervous system Intraventricular gentamicin can cause aseptic meningitis (4A). Sensory systems In 17 patients with suspected postoperative endophthalmitis treated with 0.2 mg vancomycin and 0.05 mg gentam-icin intravitreally there were adequate intrav-itreal vancomycin and gentamicin concentrations for over a week there were no adverse effects (5c). The frequency of aminoglycoside-associated hearing loss is 2-45 . Intratympanic gentam-icin therapy has gained some popularity in the treatment of...

Dihydrocodeine

Dihydrocodeine is an opioid analgesic related to codeine, in which the double bond in the 7th position is saturated. It has an analgesic potency 2-3 times that of codeine. A modified-release formulation extends the duration of action from 2-4 hours to 12 hours. In 12 volunteers who took modified-release dihydrocodeine 60 mg or 120 mg and 120 minutes later lactulose 40 mg diluted in 100 mg of water the oroce-cal transit time was significantly prolonged by dihydrocodeine compared with placebo...

Chloramphenicol

Hematologic Chloramphenicol has adverse effects on the bone-marrow, the most serious of which is aplastic anemia. It has been confirmed that chloramphenicol can cause apoptosis in purified human bone-marrow CD34+ cells (30E). Gastrointestinal In 51 children with Mediterranean spotted fever randomized for 7 days to either clarithromycin, 15 mg kg day orally in two divided doses, or chloramphenicol, 50 mg kg day orally in four divided doses, the two drugs were equally well tolerated and there...

Specific adverse effects of platinum compounds

Cardiovascular Asymptomatic sinus bradycardia e.g. 30-40 beats minute is observed within 30 minutes to 2 hours after the start of cisplatin infusion. When cisplatin is withdrawn normal rhythm is restored. Because patients who receive platins are not routinely monitored, drug-induced sinus bradycardia may not be detected in practice. However, several case reports have included heavily pretreated patients, which makes a direct correlation between cisplatin administration and the onset of...

Mexazolam

The anxiolytic effects of mexazolam have been compared with those of alprazolam in 64 outpatients with generalized anxiety disorder in a multicenter, double-blind, parallel-group, randomized trial 17C . Five mexazolam and nine alprazolam recipients reported mild adverse events drowsiness in three patients in each group dizziness in one taking mexazolam and two taking alprazolam blurred vision in one patient taking mexazolam and weight gain, nausea, and insomnia in one patient taking...