Protein A Immunoadsorption Column Prosorba

This is a device consisting of protein A from Staphylococcus bound to a silica matrix. By means of apheresis technology, potentially pathogenic IgG and IgG-containing immune complexes are removed. Refractory RA, immune thrombocytopenia purpura. Metabolism Extracorporeal passage of plasma through the immunoadsorption column is performed by means of an apheresis machine. The treated plasma is then returned to the patient. The most common adverse effects are joint pain and swelling, fatigue...

Ketoprofen Orudis Oruvail Actron

Metabolism Ketoprofen is a propionic acid derivative that is well absorbed after oral administration, but peak concentrations are delayed and reduced when the drug is administered with food. Peak plasma levels are reached at 0.5 to 2 hours, and the half-life is 2 to 4 hours. The drug is 99 bound to protein. The kidneys excrete 60 as glucuronide, and enterohepatic recirculation accounts for the other 40 . Dyspepsia, gastrointestinal ulceration, bleeding, and...

Dapsone

Possible antiinflammatory effects through inhibition of prostaglandin synthesis, complement activation, and myeloperoxidase-mediated pathways. Selected Indications Cutaneous LE, SLE. Dapsone is well absorbed within the gastrointestinal tract. Peak levels are attained within 2 to 8 hours. The half-life of the drug is about 1 day. Dapsone is partially acetylated by the liver. It and its metabolites are mostly excreted in urine about 20 is unchanged drug. Dose-dependent hemolytic anemia and...

Neurologic signs and symptoms

Paresthesias radiating from the neck to the arm are an important indicator of nerve root irritability as the origin of the pain. 2. Numbness and weakness of the arm or hand indicate more severe nerve root compromise careful neurologic examination will often localize the cervical nerve root involved (see Appendix B). 3. Patients with vertebral artery compromise may complain of dizziness, visual dysfunction, and syncopal episodes. 4. Cervical myelopathy can be identified in cases of severe...

Diltiazem Cardizem

Calcium channel blocker that dilates coronary and peripheral arteries and arterioles. Diltiazem is absorbed with peak level in 3 hours and a half-life of 4 hours. It is 80 protein-bound. There is extensive hepatic metabolism. Adverse Reactions Hypotension, bradycardia, dizziness, headache, congestive heart failure, pedal edema, nausea, and rash may occur. In Raynaud's phenomenon, all vasodilators may precipitate a vascular steal syndrome. Avoid in patients with sick sinus syndrome,...

Misoprostol Cytotec

Misoprostol is a synthetic analog of prostaglandin E 1 with protective properties against gastric inflammation and ulceration induced by NSAIDs. Selected Indications Gastroprotection against NSAIDs. Absorption of misoprostol is rapid but is diminished by food or antacids. It is converted into its active form via de-esterification. Most of the drug is excreted in urine, but dose adjustment is generally not necessary in the setting of renal impairment. Abdominal discomfort, flatulence, and...

Amlodipine Norvasc

Calcium channel blocker that dilates coronary and peripheral arteries and arterioles. Dose adjustment is not generally necessary in the setting of renal insufficiency. However, elimination can be reduced in the setting of hepatic impairment and in geriatric patients. Hypotension, bradycardia, dizziness, headache, congestive heart failure, pedal edema, nausea, and rash may occur. In Raynaud's phenomenon, all vasodilators may precipitate a vascular steal syndrome. Avoid in patients with sick...

Neurologic manifestations

Weeks to months after the onset of Lyme disease, neurologic symptoms develop in 15 to 20 of patients. Bell's palsy is particularly common. It is usually unilateral but may be sequential or bilateral. Other cranial neuropathies are less common and may occur with or without Bell's palsy. Involvement of cranial nerves III, IV, and VI may cause extraocular palsy. If the fifth cranial nerve is involved, facial dysesthesia may occur. Dizziness, otalgia, sore throat, and deafness...

Meclofenamate Sodium Meclomen

Metabolism Meclofenamate sodium is an anthranilic acid derivative. Peak plasma levels occur in 30 to 60 minutes with a half-life of about 3 hours concomitant antacid administration does not interfere with absorption. About two-thirds is excreted in the urine, mostly as the glucuronide conjugate, and about one-third appears in the feces. Gastrointestinal reactions occur more frequently than with aspirin. Diarrhea may occur in up to one-third of patients, and...