Genes and psychopharmacology exploring the interface

Biological Psychiatry Laboratory, Department of Psychiatry, Hadassah-Hebrew University Medical Center, Jerusalem, Israel Pharmacogenetics is the study of genetically determined, interindividual differences in therapeutic response to drugs and susceptibility to adverse effects. The principal objective of pharmacogenetics is to identify and categorize the genetic factors that underlie these differences and to apply these observations in the clinic. Individualization of drug treatment to the...

The pharmacogenetic trait definition and methods of analysis

A pharmacogenetic trait is a complex, multidetermined characteristic, not a disease but rather a difference in the expression of a genetically determined mechanism involved in drug metabolism (Nebert, 1999). The distinction is subtle but substantial. At variance with a common complex disorder, we do not have to detect which genes are relevant for the trait to be manifested, and then to detect their pathological variants. Rather, it should be known, more or less, from our knowledge of biology,...

Conclusions

Issues relating to pharmacogenetics have a unique role in the investigation of heritable risk factors for drug dependence. The pharmacogenetic research strategy will certainly lead to insight into disease mechanisms but will also yield clinically applicable results relatively quickly (Sellers et al., 2000). Applications will include prediction of risk in unaffected individuals, individualized selection of treatment, and development of new treatments. In a recent review article, Roses (2000)...

From pharmacogenetics to pharmacogenomics of psychotropic drug response

Hillside Hospital, Glen Oaks, New York The marked interindividual variation in response to psychotropic drugs creates a clinical dilemma that can only be resolved through often lengthy empirical drug trials. Recent developments in molecular biology have provided an opportunity to identify molecular genetic predictors of drug response, which may have immediate clinical implications as well as provide critical data for future drug development. In this chapter, we will discuss the evidence for a...