Pesticides

Organophosphorus insecticides Organophos-phorus insecticides are usually supplied as powders or dissolved in organic solvents. All are absorbed through the bronchi and intact skin as well as through the gut and inhibit cholinesterase activity, thereby prolonging and intensifying the effects of acetylcholine. Toxicity between different compounds varies considerably, and onset may be delayed after skin exposure. Anxiety, restlessness, dizziness, headache, miosis, nausea, hypersalivation,...

Nifedipine

Indications prophylaxis of angina hypertension Raynaud's phenomenon Cautions see notes above also withdraw if ischaemic pain occurs or existing pain worsens shortly after initiating treatment poor cardiac reserve heart failure or significantly impaired left ventricular function (heart failure deterioration observed) severe hypotension elderly diabetes mellitus avoid grapefruit juice (may affect metabolism) acute porphyria (but see section 9.8.2) interactions Appendix 1 (calcium-channel...

Phenoxybenzamine Hydrochloride

Indications hypertensive episodes in phaeochromo-cytoma Cautions elderly congestive heart failure severe ischaemic heart disease (see also Contra-indications) cerebrovascular disease (avoid if history of cerebro-vascular accident) monitor blood pressure regularly during infusion carcinogenic in animals avoid in acute porphyria (section 9.8.2) avoid extravasation (irritant to tissues) Contra-indications history of cerebrovascular accident during recovery period after myocardial infarction...

Hydralazine Hydrochloride

Indications moderate to severe hypertension (adjunct) heart failure (with long-acting nitrate, but see section 2.5.5) hypertensive emergencies (including during pregnancy) (see section 2.5) Cautions coronary artery disease (may provoke angina, avoid after myocardial infarction until stabilised), cerebrovascular disease occasionally blood pressure reduction too rapid even with low parenteral doses manufacturer advises test for antinuclear factor and for proteinuria every 6 months and check acet-...