Uses in Motion Sickness

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Scopolamine is useful for prevention of motion sickness when the motion is very stressful and of short duration. A transdermal preparation (Transderm-Scop) with a 72-hour duration of action has been marketed for this purpose. Blockade of cholinergic sites in the vestibular nuclei and reticular formation may account for the effectiveness of this agent. When the motion is less stressful and lasts longer, the antihistamines (H1-antagonists) are probably preferable to the antimus-

carinic drugs, especially for the prophylactic treatment of motion sickness.

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