Dmt And Related Tryptamines

AKA (DMT): Anadenanthera colubrina, Anadenanthera peregrina, Anadenanthera rigida, angico, businessman's trip, cebil, cohoba, dimethyltryptamine, hisioma, huilca, niopo, N,N-dimethyl-tryptamine, one-hit grass, parica, Pip-tadenia peregrina, sebil, vilca, yopo, yupa.

AKA (AMT): Alpha-methyltrypta-mine, IT-290.

AKA (DAT): N,N-diallyltrypta-mine.

AKA (DBT): N,N-dibutyltrypta-mine.

AKA (DHT): N,N-dihexyltrypta-mine.

AKA (DIT): N,N-diisopropyl-tryptamine.

AKA (DPT): N,N-dipropyltrypta-mine.

AKA (5-MeO-DMT): 5-methoxy-N,N-dimethyltryptamine.

AKA (5-MeO-MMT): 5-methoxy-N-monomethyltryptamine.

AKA (5-OH-DMT): Bufotenine, 5-hdroxy-N.N-dimethyltryptamine.

AKA (5-MeO-MIPT): 5-methoxy-N-methyl-N-isopropyltryptamine.

AKA (MMT): N-monomethyl-tryptamine, NMT.

Existing naturally in human cere-brospinal fluid, DMT and its precursor tryptamine are similar to certain hormones secreted by the pineal gland. Furthermore, receptors for DMT have been discovered in the brains of mammals, and it is the active hallucinogenic ingredient in several South American plants. Other related tryptamines are listed above. AMT was made famous by Ken Kesey and his Merry Pranksters, as chronicled in Tom Wolfe's The Electric Kool-Aid Acid Test.

Effects: Possibly unique among psychedelics, DMT cannot be taken orally, as stomach enzymes break it down before it can pass to the bloodstream. South American Indians use it in the form of snuff (and variously call it cebil, cohoba, huilca, niopo, sebil, vilca, or yopo), and it can also be smoked or injected intramuscularly. As a snuff, it can produce an immediate high that can last thirty minutes; when smoked, it can produce an immediate high that can last one to ten minutes. The high is similar to that of LSD or mescaline, but shorter. Parica is a generic name for snuffs of all kinds.

The tryptamine AMT produces a stimulating effect similar to LSD and amphetamines.

The tryptamine DET produces a trip that is milder and longer-lasting than DMT.

A close relative to DMT, 5-MeO-DMT is produced both synthetically and in the venom glands of the Sonoran Desert toad of Arizona. However, the two types of 5-MeO-DMT produce vastly different experiences, the former resulting in a frightening "dissolution of reality" when smoked and the toad venom producing a much gentler experience when dried and smoked. Contrary to tabloid reports, only the Sonoran Desert toad has venom that is psychoactive (other toad venoms are just toxic), though it can cause a serious case of poisoning if brought into contact with the eyes or mouth.

Precautions: Some characterize the odor of DMT as the smell of burning plastic, which may be due to the contaminant skatole. The psychedelic trip may be accompanied by dizziness, rapid heart and respiratory rates, disorientation, and confusion. If taken on a full stomach, DMT could cause nausea. An overdose could result in blood rushing to the head and rupturing weak capillaries. Addiction is unknown, though tolerance is rapid, and like any psychedelic, it can result in bad trips.

An MAO inhibitor, DMT may cause severe headaches, vomiting, dangerously high blood pressure, heart problems, and even death when combined with avocados, bananas, broad beans, caffeine, aged cheeses, chicken liver, chocolate, cocoa, dill oil, fennel oil, canned figs, pickled herring, licorice, milk or milk products, nutmeg, parsley oil, pineapple, sauerkraut, yeast extract, alcohol, amphetamines, antihistamines, atropine, ephedrine, insulin, mescaline, narcotics, ritalin, sedatives, or tranquilizers.

Jonathan Ott and others have concluded that 5-MeO-DMT has "little recreational value," essentially agreeing with a colleague who compared it to "having a large elephant sitting on one's head." It should be noted that, since most types of toad venom are toxic, licking toads can be dangerous, and getting the venom in the eyes or mouth can cause severe poisoning. The venom must be dried and smoked to inactivate the toxins.

Reportedly, 5-MeO-MIPT acts more like amphetamines, providing stimulation without the hallucinations.

The reported hallucinogenic effects of 5-OH-DMT are disputed by research, which also suggests that it creates cardiopulmonary distress and may be toxic even in doses as low as 10 mg when injected intravenously. A CIA experiment nearly killed three individuals with 2.5 to 5 mg of an intramuscular injection after they were premedicated with reserpine and chlorpromazine.

Dosage: Readily snorted, eaten, and injected, DMT (in a dose of 3.5 to 5 mg) can also be combined with marijuana, parsley, or tobacco and smoked; there are several methods used to prepare the seeds for consumption. Writer William Burroughs self-experimented with DMT in doses of around 65 mg; he accidentally overdosed at 100 mg, producing a traumatic experience that left him leery of the drug afterward. Timothy Leary and Ralph Metzner reported no ill effects at doses of 1 mg/kg of body weight. The CIA experimented on prison inmates and mental patients, revealing that the snuff is inactive in doses up to 1 gram, and oral doses are inactive up to 350 mg, but intramuscular injections produced visual hallucinations with as little as 10 to 12.5 mg. According to Jonathan Ott,

DMT is not active orally. Single doses of up to a gram orally have no effect Similarly, rectal doses of up to 125 mg DMT in 15 ml water were "without any discernable effect" ... The average intramuscular dose of the hydrochloride salt is 50 to 60 mg, producing an entheogenic effect commencing in 2 to 5 minutes, peaking in 15 minutes, with the experience lasting a total of 30 to 45 minutes. An effect of equal intensity is produced by 25 to 30 mg of DMT free base smoked, with the entire experience accelerated dramatically. The onset following smoking is almost immediate, attaining a peak in 2 to 3 minutes, with the entire effect lasting only 10 to 20 minutes Although DMT-containing plant snuffs are active, intranasal administrations of 5 to 20 mg of pure DMT was inactive Orally, in combination with MAO-inhibitors, DMT is active in the same dose range as by intramuscular injection. Tolerance to the entheogenic effects of DMT develop rapidly, but dissipates rapidly as well, and DMT and LSD show crosstolerance. Allowing about four hours between doses has been reported to avoid tolerance.

The effective oral dose of AMT appears to be approximately 20 mg.

Unlike DMT, DET is active orally, but only at high doses; when smoked or injected, its potency is roughly equivalent to that of DMT (a dose of 50-60 mg takes effect in 15 minutes, peaks quickly, and lasts 2 to 3 hours).

The effects of DPT are nearly identical to those of DET, with one exception: above 100 mg, the duration of the effects is dependent upon the dosage.

Unless combined with MAO inhibitors at a 10 mg dose, 5-MeO-DMT is not active orally. When smoked, it is four times as potent as DMT. Experiments have found that smoking 6 to 10 mg of the free base can result in a high that begins within a minute, peaks after two, and lasts twenty. Parenteral injections of 5 to 10 mg were also found to produce results.

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