Clinical Appearence Classification

DH most commonly manifests itself in early adult life, but is also found in childhood or in elderly patients. A slight male predominance has been noted (Fry 2002). Typically, patients with DH display an intense pruritic eruption of erythematous papules or vesicles. The lesions are distributed symmetrically on the extensor surfaces. Areas of predilection include elbows, knees, sacrum, Table 1. Milestones in Studies on Dermatitis Herpetiformis (DH) Clinical description and introduction of the...

Immunogenetics

The earliest immunogenetic studies on SCLE patients suggested an association with several HLA class II phenotypes. HLA-DR3, a phenotype found in 25 of Caucasians in the US (Ahearn et al. 1982), was reported in some studies in at least half of SCLE patients (Sontheimer 1989 Vasquez-Doval et al. 1992), while others reported a lower frequency (Callen and Klein 1988 Drosos et al. 1990 Cohen and Crosby 1994). HLA-DR3 expression has been associated with annular more than papulosquamous SCLE lesions...

Epidemiology of Pemphigus and Association with HLA Class II Alleles

PV is the most common form of pemphigus but still a rare disease, the incidence varying from 0.1-0.5 per 100,000 population and being higher among Jewish patients Ahmed et al. 1990 . In areas where PV and PF are endemic, however, the ratio of cases of PF to cases of PV is nearly 20 to 1. In Brazil, some 15,000 patients are known to have PF, and the prevalence of the disorder is 3.4 percent in regions such as the Amerindian reservation of Limao Verde Warren et al. 2000 . Several epidemiological...