Linkage Disequilibrium

Two linked loci are said to be in linkage disequilibrium if specific combinations of alleles at the loci are seen together on chromosomes more often than expected by chance. For example, if die frequency of allele 1 at locus A Al is 0.7 in a population and the frequency of allele 1 at locus B Bl is 0.6, then the expected proportion of chromosomes bearing the combination Al Bl is given by the product of the frequencies of Al and Bl 0.7 X 0.6 0.42. If we examine a series of chromosomes in a...