Angiogenesis

It has been postulated that limb defects seen with thalidomide are secondary to an inhibition of blood vessel growth in the developing fetal limb bud (22). The limb bud is unique in requiring a complex interaction of a number of processes including angiogen-esis. S ince angiogenesis is the formation of new blood vessels from sprouts of preexisting vessels, the limb bud would be a particularly vulnerable target to a teratogen that inhibited vascular endothelial growth. Thalidomide has recently...