Clinical Implications

Cardiovascular denervation can give rise to a number of clinical syndromes including impaired exercise-induced cardiovascular performance, orthostatic hypotension, and the cardiac denervation syndrome (Table 2). Abnormal Cardiovascular Exercise Performance Advanced CAN might impair cardiovascular performance during exercise (51), which might be subclinical (52,53). CAN might be accompanied by impaired LV function, which encompasses a spectrum of different deficits (see Cardiac Denervation...

Info

Sb, single blind db, double-blind Uncntr, uncontrolled nonrmd, nonrandomized rmd, randomized co, crossover mcv, motor nerve conduction velocity scv, sensory nerve conduction velocity sap, sensory action potential wl, wave latency dsl, distal sensory latency VPT, vibration perception threshold mfd, myelinated fibre density. sb, single blind db, double-blind Uncntr, uncontrolled nonrmd, nonrandomized rmd, randomized co, crossover mcv, motor nerve conduction velocity scv, sensory nerve conduction...

SUMMARY

Orthostatic hypotension OH occurs in 10-20 of patients seen in diabetic practice. Patients can be asymptomatic or manifest symptoms of cerebral hypoperfusion, such as lightheadedness or weakness, or less common symptoms of sympathetic overactivity. Syncope can occur. Symptoms correlate with autonomic deficits. Autonomic laboratory evaluation demonstrates early impairment of cardiovagal and distal postganglionic sudomotor function, eventually leading to generalized autonomic failure. Treatment...