Chronic exposure

Systemic effects from chronic exposure (dermal and or inhalation) Chronic exposure to glycol ethers may cause encephalopathy which is characterised by gradual onset of personality changes, confusion, headache, dizziness, lethargy, fatigue and abnormal sleepiness. There may also be staggering gait, blurred vision, slurred speech, nausea, vomiting, anorexia and weight loss, agitation, irritability and poor concentration, orientation, reasoning and memory (Parsons and Parsons, 1938 Zavon, 1963 Ohi...

Carbon Tetrachloride Throat Irritation

Inhalation of white spirit can cause nausea, vomiting, headache, dizziness, mild respiratory tract irritation, euphoria and CNS depression. Acute exposure to 470 ppm white spirit caused transient eye irritation and dizziness (Carpenter et al., 1975). Nelson (1943) also observed that concentrations of > 400 ppm were required to develop eye irritation, and in this study subjects also reported nose and throat irritation, but no effects below this exposure concentration. Severe CNS depression is...

Acute exposure

Acute effects from occupational exposure to chloroform are uncommon (Harbison and Sleeman, 1998) and are most likely to occur following an industrial accident. Chloroform does not appear to cause respiratory irritation but the breath usually has a chloroform odour. Systemic effects are likely - see below. Table 5.1 describes the physiological response to varying concentrations (in air) of chloroform in humans. Table 5.1 describes the physiological response to varying concentrations (in air) of...

Acute exposure Inhalation

1,1,1-TCE vapours are irritating to the eyes and mucous membranes causing coughing and chest tightness as the concentration increases (IPCS, 1992). It has a depressant action on the CNS and is narcotic at high concentrations. With intentional abuse an initial excitatory phase occurs which may be followed by depression and a hangover effect (similar although less severe than that caused by alcohol) (Watson, 1982). This initial euphoria may progress to confusion, disorientation, dizziness,...