Chronic exposure

Lassitude, dry mouth, thirst, gastrointestinal discomfort, loss of appetite, ataxia, urinary frequency, inability to concentrate and dizziness have been reported in workers exposed to chloroform (77-237 ppm). Liver function tests were normal in all workers, but no biopsies were performed (Challen et al., 1958). Nausea and vomiting has also been reported (Phoon et al., 1975). Li et al. (1993) reported dizziness, fatigue, drowsiness, hypomnesia (memory impairment), increased dreams, anorexia and...

Carbon Tetrachloride Throat Irritation

Inhalation of white spirit can cause nausea, vomiting, headache, dizziness, mild respiratory tract irritation, euphoria and CNS depression. Acute exposure to 470 ppm white spirit caused transient eye irritation and dizziness (Carpenter et al., 1975). Nelson (1943) also observed that concentrations of > 400 ppm were required to develop eye irritation, and in this study subjects also reported nose and throat irritation, but no effects below this exposure concentration. Severe CNS depression is...

Acute exposure

Acute effects from occupational exposure to chloroform are uncommon (Harbison and Sleeman, 1998) and are most likely to occur following an industrial accident. Chloroform does not appear to cause respiratory irritation but the breath usually has a chloroform odour. Systemic effects are likely - see below. Table 5.1 describes the physiological response to varying concentrations (in air) of chloroform in humans. Table 5.1 describes the physiological response to varying concentrations (in air) of...

Acute exposure Inhalation

1,1,1-TCE vapours are irritating to the eyes and mucous membranes causing coughing and chest tightness as the concentration increases (IPCS, 1992). It has a depressant action on the CNS and is narcotic at high concentrations. With intentional abuse an initial excitatory phase occurs which may be followed by depression and a hangover effect (similar although less severe than that caused by alcohol) (Watson, 1982). This initial euphoria may progress to confusion, disorientation, dizziness,...