Adverse Reactions

According to clinical trials A. hippocastanum and HCSE appear to be well tolerated with only mild, infrequent reports of adverse reactions including gastric irritation, skin irritation, dizziness, nausea, headache and pruritus. Post marketing surveillance reports adverse effects of 0.7 (Micromedex 2003, NMCD 2006, PDRHealth 2006, Pittler & Ernst 2004, Siebert et al 2002). Horse chestnut contains a toxic glycoside esculin (aesculin), a hydroxycoumarin that may increase bleeding time because...

Clinical Use

Although ginger is used in many forms, including fresh ginger used in cooking or chai (Indian spicy tea), pickled or glazed ginger, ethanol extracts and concentrated powdered extracts, preparations made with the root are used medicinally. Depending on the specific solvent used, the resultant preparation will contain different concentrations of the active constituents and may differ markedly from crude ginger. Although the great majority of research refers specifically to the species Zingiber...

Cardiovascular Diseases

In 1972 Folkers and Littaru from Italy documented a deficiency of coenzyme Q10 in human heart disease (Ernster & Dallner 1995). Since those early reports, a steady stream of research articles have been published and clinical experience in its use as an adjunct to conventional treatment in various forms of heart disease has accumulated. Data from laboratory studies have also accumulated and generally provide a supportive basis for its use. A review by Langsjoen and Langsjoen of over 34...