Linkage Disequilibrium Ld Mapping And Identical By Descent Ibd Mapping

When marker and QTL are very close together, or when the marker is within the DNA sequence of the gene itself, a situation may arise in which there is an excess of some haplotypes and a deficiency of others across the population as a whole. This condition, termed linkage disequilibrium (LD), can be uncovered by an association test, which compares average trait value of the different genotypes at a marker across the population as a whole. Finding marker QTL LD indicates that the marker involved is very close to the QTL. Linkage disequilibrium can be generated by the random accumulation of small changes in frequency of the various marker QTL haplotypes over many generations. Identical by descent (IBD) mapping is based on the assumption that the mutation that produced a specific positive or negative QTL allele was a unique event that took place in a single ancestor chromosome, and will hence be in association with the specific marker alleles found in the haplotype of the ancestor chromosome within which the mutation arose. Thus, IBD mapping can lead to the very gene underlying the QTL.

Natural Vertigo And Dizziness Relief

Natural Vertigo And Dizziness Relief

Are you sick of feeling like the whole world Is spinning out of control. Do You Feel Weak Helpless Nauseous? Are You Scared to Move More Than a Few Inches From The Safety of Your Bed! Then you really need to read this page. You see, I know exactly what you are going through right now, believe me, I understand because I have been there & experienced vertigo at it's worst!

Get My Free Ebook


Post a comment